Application of Bromate-Bromide Mixture as a Green Brominating Agent for the Determination of Fexofenadine Hydrochloride in Pharmaceutical Dosage Form

Fexofenadine hydrochloride (FFH), chemically known as (±)-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-a,a-dimethyl benzene aceticacid hydrochloride [1] is a active metabolite of terfenadine and is a second-generation histamine H1-receptor antagonist in piperidine-class drugs. These drugs are used in the treatment of seasonal allergic rhinitis, chronic idiopathic urticaria etc. FFH is a H1-receptor antagonist that blocks peripheral histamine H1-receptors selectively. It does not cause sedation or other central nervous system effects because it does not cross the blood–brain barrier [2] (Figure 1).